Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 14/20 | 0.43 |
| ▸ | JAK2 | O60674 | 8/20 | 0.43 |
| ▸ | GCK | P35557 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29747664 | 0.85 | GCK (0.40) | RIPK1GCK | |
| SCHEMBL17848871 | 0.81 | SCN9A (0.42) | RIPK1NTRK1JAK2HCRTR2 | |
| SCHEMBL29525364 | 0.80 | NTRK1 (0.50) | RIPK1NTRK1JAK2 | |
| SCHEMBL30148073 | 0.80 | NTRK1 (0.50) | RIPK1NTRK1JAK2 | |
| SCHEMBL932475 | 0.80 | NTRK1 (0.50) | RIPK1NTRK1JAK2 | |
| SCHEMBL932474 | 0.80 | NTRK1 (0.50) | RIPK1NTRK1JAK2 | |
| SCHEMBL29891866 | 0.78 | HTR2A (0.39) | — | |
| SCHEMBL932557 | 0.78 | NTRK1 (0.44) | RIPK1NTRK1JAK2HCRTR2 | |
| SCHEMBL28674970 | 0.77 | AGTR2 (0.50) | RIPK1NTRK1JAK2AGTR2 | |
| SCHEMBL29924546 | 0.77 | TMEM97 (0.39) | RIPK1GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451812-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2012-05-16 | — | — | EP | disclosed |
| EP-2350075-A1 | SUBSTITUTED IMIDAZOÝ1,2B¨PYRIDAZINE COMPOUNDS AS TRK KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |
| EP-2350071-A1 | SUBSTITUTED PYRAZOLOÝ1,5-a¨PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |
| WO-2011006074-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-01-13 | — | — | WO | disclosed |
| WO-2010048314-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010033941-A1 | SUBSTITUTED IMIDAZO[1,2B]PYRIDAZINE COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2010-03-25 | — | — | WO | disclosed |