Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12525209 | 0.84 | LRRK2 (0.53) | LRRK2HPGDALDH1A1POLBPDK2 | |
| SCHEMBL22012072 | 0.82 | HDAC1 (0.47) | HPGDALDH1A1PLA2G1BATG4BGAA | |
| SCHEMBL3454797 | 0.80 | HPGD (0.59) | LRRK2HPGDALDH1A1POLBPLA2G1B | |
| SCHEMBL12526825 | 0.80 | LRRK2 (0.68) | LRRK2HPGDALDH1A1HSD17B10PKM | |
| SCHEMBL11293154 | 0.80 | HPGD (0.73) | LRRK2HPGDALDH1A1POLBPKM | |
| SCHEMBL21938853 | 0.79 | HSD11B1 (0.50) | LRRK2HPGDALDH1A1POLBPLA2G1B | |
| SCHEMBL12525213 | 0.79 | POLB (0.62) | LRRK2HPGDALDH1A1POLBPKM | |
| SCHEMBL15653084 | 0.78 | LRRK2 (0.63) | LRRK2HPGDHSD17B10PKMHSD11B1 | |
| SCHEMBL15653083 | 0.78 | LRRK2 (0.63) | LRRK2HPGDHSD17B10PKMHSD11B1 | |
| SCHEMBL15172215 | 0.78 | GAA (0.55) | LRRK2HPGDALDH1A1POLBPLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371319-B2 | Pyrrolopyridineamino derivatives as MPS1 inhibitors | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2016-06-21 | — | — | US | disclosed |