Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.43 |
| ▸ | CPS1 | P31327 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17849533 | 0.82 | LRRK2 (0.56) | PDK2KMT2APLA2G1BATG4BGAA | |
| SCHEMBL6838922 | 0.80 | PLA2G7 (0.57) | HDAC1HDAC6KMT2AMEN1ALDH1A1 | |
| SCHEMBL21962176 | 0.80 | SMN1; SMN2 (0.55) | HDAC1HDAC6KMT2AMEN1ALDH1A1 | |
| SCHEMBL355576 | 0.80 | HPGD (0.56) | HDAC1HDAC6KMT2AMEN1ALDH1A1 | |
| SCHEMBL15651449 | 0.79 | HSD11B1 (0.48) | HDAC1HDAC6KMT2AMEN1ALDH1A1 | |
| SCHEMBL21938853 | 0.79 | HSD11B1 (0.50) | PLA2G1BATG4BALDH1A1HSD11B1CPS1 | |
| SCHEMBL15651448 | 0.79 | HSD11B1 (0.48) | HDAC1HDAC6KMT2AMEN1ALDH1A1 | |
| SCHEMBL16982524 | 0.79 | KMT2A (0.75) | HDAC1HDAC6KMT2AMEN1HPGD | |
| SCHEMBL13451259 | 0.78 | HSD11B1 (0.52) | HDAC1HDAC6KMT2AMEN1ALDH1A1 | |
| SCHEMBL22650841 | 0.77 | L3MBTL3 (0.56) | PDK2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102576-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |