Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12110927 | 0.86 | ALDH1A1 (0.42) | ALDH1A1KDM4ECRBNGAAMAPT | |
| SCHEMBL18766568 | 0.82 | ALDH1A1 (0.47) | ALDH1A1KDM4ECRBNGAAMAPT | |
| SCHEMBL17849862 | 0.82 | ALDH1A1 (0.47) | ALDH1A1KDM4ECRBNGAAMAPT | |
| SCHEMBL12110918 | 0.82 | KDM4E (0.38) | ALDH1A1KDM4ECRBNGAAMAPT | |
| SCHEMBL12110798 | 0.82 | KDM4E (0.38) | ALDH1A1KDM4ECRBNGAAMAPT | |
| SCHEMBL5579426 | 0.78 | ALDH1A1 (0.53) | ALDH1A1KDM4ECRBNGAAMAPT | |
| SCHEMBL27123348 | 0.78 | ALDH1A1 (0.53) | ALDH1A1KDM4ECRBNGAAMAPT | |
| SCHEMBL17849875 | 0.78 | ALDH1A1 (0.42) | ALDH1A1KDM4ECRBNGAAMAPT | |
| SCHEMBL17849858 | 0.78 | ALDH1A1 (0.42) | ALDH1A1KDM4ECRBNGAAMAPT | |
| SCHEMBL17849876 | 0.74 | RIPK1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371283-B2 | Polycyclic tetracycline compounds | TETRAPHASE PHARMACEUTICALS, INC. (US) | 2016-06-21 | — | — | US | disclosed |