Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.41 |
| ▸ | FLT1 | P17948 | 3/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.39 |
| ▸ | ITK | Q08881 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10194994 | 0.80 | RBP4 (0.44) | FGFR1FLT1RBP4 | |
| SCHEMBL10194985 | 0.78 | HTR2C (0.42) | FGFR1FLT1ITKGRM4IRAK4 | |
| SCHEMBL10194980 | 0.78 | HTR2C (0.42) | FLT1IRAK4MAPK8MAPK9PIM1 | |
| SCHEMBL10194956 | 0.77 | FGFR1 (0.44) | FGFR1FLT1ABL1LRRK2GRM4 | |
| SCHEMBL10194973 | 0.75 | FGFR1 (0.46) | FGFR1FLT1LRRK2ITKGRM4 | |
| SCHEMBL9959526 | 0.75 | DRD2 (0.39) | FGFR1FLT1ABL1LRRK2GRM4 | |
| SCHEMBL10195395 | 0.74 | P2RY14 (0.46) | LRRK2GRM4IRAK4MAPK8MAPK9 | |
| SCHEMBL10195390 | 0.74 | DRD2 (0.45) | FGFR1FLT1LRRK2GRM4IRAK4 | |
| Hydrochloric Acid SCHEMBL9959222 | 0.74 | P2RY14 (0.46) | LRRK2GRM4IRAK4MAPK8MAPK9 | |
| SCHEMBL9952579 | 0.73 | FLT3 (0.47) | GRM4ROCK2ROCK1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655357-B1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO SA (CH) | 2016-06-22 | — | — | EP | disclosed |