Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.35 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17850586 | 0.88 | EPHX1 (0.40) | LMNAEPHX1CA12CA1CA2 | |
| SCHEMBL17850637 | 0.85 | CA12 (0.46) | LMNAEPHX1CA12CA1CA2 | |
| SCHEMBL19981641 | 0.80 | ALDH1A1 (0.46) | LMNAEPHX1CA12CA1CA2 | |
| SCHEMBL13627778 | 0.77 | EPHX1 (0.39) | EPHX1PRMT3ALDH1A1HSD17B10TSHR | |
| SCHEMBL24869141 | 0.77 | LMNA (0.46) | LMNACA12CA1CA2CA9 | |
| SCHEMBL17850653 | 0.76 | EPHX1 (0.49) | EPHX1CA12CA1CA2CA9 | |
| SCHEMBL19398656 | 0.74 | LMNA (0.52) | LMNACA12CA1CA2CA9 | |
| SCHEMBL11922838 | 0.72 | LMNA (0.41) | LMNACA12CA1CA2CA9 | |
| SCHEMBL1241071 | 0.72 | LMNA (0.50) | LMNACA12CA1CA2CA9 | |
| SCHEMBL9404556 | 0.71 | GAA (0.57) | EPHX1MAPTALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2714036-B1 | SUBSITUTED ALIPHANES, CYCLOPHANES, HETERAPHANES, HETEROPHANES, HETERO-HETERAPHANES AND METALLOCENES USEFUL FOR TREATING HCV INFECTIONS | ACHILLION PHARMACEUTICALS INC (US) | 2016-06-22 | — | — | EP | disclosed |