Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | KDM5A | P29375 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 4/20 | 0.35 |
| ▸ | CA9 | Q16790 | 4/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | PYGL | P06737 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | KDM5C | P41229 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17850637 | 0.85 | CA12 (0.46) | EPHX1CYP2D6KDM5AALDH1A1HPGD | |
| SCHEMBL17850586 | 0.84 | EPHX1 (0.40) | EPHX1CYP2D6KDM5AALDH1A1HPGD | |
| SCHEMBL31549433 | 0.81 | ACHE (0.51) | EPHX1ACHE | |
| SCHEMBL3757130 | 0.80 | TDP1 (0.44) | EPHX1ALDH1A1CA12CA9CA1 | |
| SCHEMBL31201814 | 0.80 | TDP1 (0.44) | EPHX1ALDH1A1CA12CA9CA1 | |
| SCHEMBL30199943 | 0.77 | CA12 (0.41) | EPHX1KDM5ACA12CA9CA1 | |
| SCHEMBL3236942 | 0.77 | KDM5A (0.41) | EPHX1KDM5ACA12CA9CA1 | |
| SCHEMBL18314854 | 0.77 | CA12 (0.41) | EPHX1KDM5ACA12CA9CA1 | |
| SCHEMBL17850573 | 0.76 | LMNA (0.43) | EPHX1CYP2D6ALDH1A1HPGDCA12 | |
| SCHEMBL20333407 | 0.76 | DNM1 (0.41) | EPHX1KDM5ACA12CA9CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2714036-B1 | SUBSITUTED ALIPHANES, CYCLOPHANES, HETERAPHANES, HETEROPHANES, HETERO-HETERAPHANES AND METALLOCENES USEFUL FOR TREATING HCV INFECTIONS | ACHILLION PHARMACEUTICALS INC (US) | 2016-06-22 | — | — | EP | disclosed |