Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 7/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.35 |
| ▸ | RECQL | P46063 | 3/20 | 0.35 |
| ▸ | GRK2 | P25098 | 2/20 | 0.35 |
| ▸ | APAF1 | O14727 | 2/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL178540 | 0.84 | SMN1; SMN2 (0.41) | CHRNB4CHRNA3POLBTDP1RECQL | |
| SCHEMBL178518 | 0.81 | ALDH1A1 (0.51) | POLBTDP1RECQLALDH1A1HTT | |
| SCHEMBL178532 | 0.81 | CHRNB4 (0.37) | CHRNB4CHRNA3POLBTDP1CA1 | |
| SCHEMBL10227364 | 0.81 | KIF11 (0.38) | CHRNB4CHRNA3POLBTDP1RECQL | |
| SCHEMBL178521 | 0.79 | CLK4 (0.38) | CHRNB4CHRNA3 | |
| SCHEMBL178562 | 0.78 | NOTUM (0.36) | CHRNB4CHRNA3HTTNPC1RAB9A | |
| SCHEMBL178535 | 0.78 | ALDH1A1 (0.40) | CHRNB4CHRNA3TDP1ALDH1A1HTT | |
| SCHEMBL13927248 | 0.77 | CHRNB4 (0.34) | CHRNB4CHRNA3RECQLHTTNPC1 | |
| SCHEMBL100640 | 0.77 | POLB (0.31) | POLBALDH1A1HTTLMNANPSR1 | |
| SCHEMBL12904308 | 0.74 | MIF (0.43) | ALDH1A1HTTNPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120059015-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS AS MGLU5 ANTAGONISTS | RECORDATI IRELAND LTD. (IT) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120059015-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS AS MGLU5 ANTAGONISTS | GRM5, GPR65, GRIK5 | CHRNB4 212/4885CHRNA3 112/4885POLB 4532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.