Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PRF1 | P14222 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | F7 | P08709 | 1/20 | 0.33 |
| ▸ | F3 | P13726 | 1/20 | 0.33 |
| ▸ | PAFAH1B2 | P68402 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3342164 | 0.95 | RORC (0.47) | RORCHDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL12607762 | 0.88 | RORC (0.50) | RORCHDAC1HDAC8HDAC3HDAC2 | |
| Trifluoroacetic Acid SCHEMBL1787276 | 0.84 | HDAC1 (0.37) | RORCHDAC1NPC1RAB9ASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL3345415 | 0.78 | HDAC1 (0.40) | RORCHDAC1HDAC6NPC1RAB9A | |
| SCHEMBL16195325 | 0.77 | HDAC3 (0.39) | HDAC1HDAC8HDAC3HDAC2NPC1 | |
| Trifluoroacetic Acid SCHEMBL3342509 | 0.77 | OPRM1 (0.41) | RORCHDAC1HDAC8HDAC3HDAC2 | |
| Trifluoroacetic Acid SCHEMBL1787305 | 0.75 | OPRM1 (0.44) | RORCHDAC1HDAC8HDAC3HDAC2 | |
| Trifluoroacetic Acid SCHEMBL3345691 | 0.75 | HDAC1 (0.52) | RORCHDAC1NPC1RAB9ASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL1787859 | 0.75 | KDM4E (0.44) | HDAC1NPC1RAB9ASMN1; SMN2OPRM1 | |
| SCHEMBL1785224 | 0.74 | OPRM1 (0.42) | RORCHDAC1HDAC8HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8633175-B2 | Compounds as antagonists or inverse agonists at opioid receptors | GLAXOSMITHKLINE LLC (US) | 2014-01-21 | — | — | US | disclosed |
| US-20110124559-A1 | NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS | SMITHKLINE BEECHAM CORPORATION (US) | 2011-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110124559-A1 | NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS | OPRL1, OPRM1, OPRK1 | RORC 549/4885HDAC1 2440/4885HDAC8 2033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.