Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 6/20 | 0.55 |
| ▸ | PLCG1 | P19174 | 4/20 | 0.52 |
| ▸ | PLCB3 | Q01970 | 4/20 | 0.52 |
| ▸ | CASP6 | P55212 | 1/20 | 0.51 |
| ▸ | APOB | P04114 | 6/20 | 0.35 |
| ▸ | MTTP | P55157 | 6/20 | 0.35 |
| ▸ | SMO | Q99835 | 1/20 | 0.34 |
| ▸ | OGA | O60502 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17860385 | 0.92 | PAX8 (0.57) | PAX8PLCG1PLCB3CASP6 | |
| SCHEMBL17860468 | 0.90 | PAX8 (0.65) | PAX8PLCG1PLCB3CASP6APOB | |
| SCHEMBL16984262 | 0.90 | PAX8 (0.65) | PAX8PLCG1PLCB3CASP6APOB | |
| SCHEMBL17860300 | 0.90 | PAX8 (0.60) | PAX8PLCG1PLCB3CASP6APOB | |
| SCHEMBL16980367 | 0.90 | PAX8 (0.65) | PAX8PLCG1PLCB3CASP6APOB | |
| SCHEMBL17860402 | 0.88 | PAX8 (0.62) | PAX8PLCG1PLCB3CASP6APOB | |
| SCHEMBL17860304 | 0.87 | PAX8 (0.49) | PAX8PLCG1PLCB3CASP6OGA | |
| SCHEMBL17860473 | 0.86 | CASP6 (0.51) | PAX8PLCG1PLCB3CASP6OGA | |
| SCHEMBL17860519 | 0.86 | PAX8 (0.60) | PAX8PLCG1PLCB3CASP6APOB | |
| SCHEMBL17860362 | 0.86 | PAX8 (0.69) | PAX8PLCG1PLCB3CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100711-A1 | MODULATORS OF HEPATIC LIPOPROTEIN METABOLISM | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | disclosed |