Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 5/20 | 0.64 |
| ▸ | PLCG1 | P19174 | 4/20 | 0.61 |
| ▸ | PLCB3 | Q01970 | 4/20 | 0.61 |
| ▸ | CASP6 | P55212 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17860464 | 0.93 | PAX8 (0.69) | PAX8PLCG1PLCB3CASP6ROCK2 | |
| SCHEMBL17860363 | 0.92 | PAX8 (0.68) | PAX8PLCG1PLCB3CASP6MAPT | |
| SCHEMBL17860371 | 0.91 | PAX8 (0.67) | PAX8PLCG1PLCB3CASP6ROCK2 | |
| SCHEMBL17860453 | 0.91 | PAX8 (0.73) | PAX8PLCG1PLCB3CASP6NPC1 | |
| SCHEMBL16980367 | 0.90 | PAX8 (0.65) | PAX8PLCG1PLCB3CASP6MAPT | |
| SCHEMBL16984262 | 0.90 | PAX8 (0.65) | PAX8PLCG1PLCB3CASP6MAPT | |
| SCHEMBL17860468 | 0.90 | PAX8 (0.65) | PAX8PLCG1PLCB3CASP6MAPT | |
| SCHEMBL17860394 | 0.90 | PAX8 (0.65) | PAX8PLCG1PLCB3CASP6ROCK2 | |
| SCHEMBL16980396 | 0.89 | PAX8 (0.66) | PAX8PLCG1PLCB3CASP6MEN1 | |
| SCHEMBL17860454 | 0.89 | PAX8 (0.61) | PAX8PLCG1PLCB3CASP6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100711-A1 | MODULATORS OF HEPATIC LIPOPROTEIN METABOLISM | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | disclosed |