Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 3/20 | 0.69 |
| ▸ | PLCG1 | P19174 | 4/20 | 0.60 |
| ▸ | PLCB3 | Q01970 | 4/20 | 0.60 |
| ▸ | CASP6 | P55212 | 1/20 | 0.54 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17860368 | 0.93 | PAX8 (0.64) | PAX8PLCG1PLCB3CASP6MAPK14 | |
| SCHEMBL17860297 | 0.90 | PAX8 (0.72) | PAX8PLCG1PLCB3CASP6L3MBTL1 | |
| SCHEMBL17860372 | 0.90 | PAX8 (0.69) | PAX8PLCG1PLCB3CASP6MAPK14 | |
| SCHEMBL17860462 | 0.90 | PAX8 (0.71) | PAX8PLCG1PLCB3CASP6MAPK14 | |
| SCHEMBL17860449 | 0.90 | PAX8 (0.84) | PAX8PLCG1PLCB3CASP6CCR2 | |
| SCHEMBL17860362 | 0.88 | PAX8 (0.69) | PAX8PLCG1PLCB3CASP6MAPK14 | |
| SCHEMBL17860454 | 0.88 | PAX8 (0.61) | PAX8PLCG1PLCB3CASP6 | |
| SCHEMBL17860363 | 0.88 | PAX8 (0.68) | PAX8PLCG1PLCB3CASP6L3MBTL1 | |
| SCHEMBL17860453 | 0.87 | PAX8 (0.73) | PAX8PLCG1PLCB3CASP6ACKR3 | |
| SCHEMBL17860371 | 0.87 | PAX8 (0.67) | PAX8PLCG1PLCB3CASP6MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100711-A1 | MODULATORS OF HEPATIC LIPOPROTEIN METABOLISM | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | disclosed |