Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 3/20 | 0.69 |
| ▸ | PLCG1 | P19174 | 4/20 | 0.60 |
| ▸ | PLCB3 | Q01970 | 4/20 | 0.60 |
| ▸ | CASP6 | P55212 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17860394 | 0.93 | PAX8 (0.65) | PAX8PLCG1PLCB3CASP6ROCK2 | |
| SCHEMBL17860297 | 0.91 | PAX8 (0.72) | PAX8PLCG1PLCB3CASP6MEN1 | |
| SCHEMBL17860462 | 0.90 | PAX8 (0.71) | PAX8PLCG1PLCB3CASP6ROCK2 | |
| SCHEMBL17860449 | 0.90 | PAX8 (0.84) | PAX8PLCG1PLCB3CASP6ROCK2 | |
| SCHEMBL17860464 | 0.90 | PAX8 (0.69) | PAX8PLCG1PLCB3CASP6ROCK2 | |
| SCHEMBL17860362 | 0.89 | PAX8 (0.69) | PAX8PLCG1PLCB3CASP6MAPK14 | |
| SCHEMBL17860363 | 0.88 | PAX8 (0.68) | PAX8PLCG1PLCB3CASP6NPC1 | |
| SCHEMBL17860453 | 0.88 | PAX8 (0.73) | PAX8PLCG1PLCB3CASP6NPC1 | |
| SCHEMBL17860371 | 0.88 | PAX8 (0.67) | PAX8PLCG1PLCB3CASP6ROCK2 | |
| SCHEMBL16980371 | 0.87 | PAX8 (0.62) | PAX8PLCG1PLCB3CASP6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100711-A1 | MODULATORS OF HEPATIC LIPOPROTEIN METABOLISM | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | disclosed |