Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.61 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | GPR183 | P32249 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 2/20 | 0.44 |
| ▸ | CTSK | P43235 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSC | P53634 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 2/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17843469 | 1.00 | MBTD1 (0.61) | MBTD1L3MBTL3MEN1KMT2AALDH1A1 | |
| SCHEMBL17861034 | 1.00 | MBTD1 (0.61) | MBTD1L3MBTL3MEN1KMT2AALDH1A1 | |
| SCHEMBL3711656 | 0.92 | MBTD1 (0.59) | MBTD1L3MBTL3MEN1KMT2AALDH1A1 | |
| SCHEMBL17843466 | 0.92 | MBTD1 (0.59) | MBTD1L3MBTL3MEN1KMT2AALDH1A1 | |
| SCHEMBL17861096 | 0.92 | MBTD1 (0.59) | MBTD1L3MBTL3MEN1KMT2AALDH1A1 | |
| SCHEMBL3711340 | 0.91 | MBTD1 (0.68) | MBTD1L3MBTL3MEN1KMT2AALDH1A1 | |
| SCHEMBL17843460 | 0.88 | MBTD1 (0.56) | MBTD1L3MBTL3MEN1KMT2AALDH1A1 | |
| SCHEMBL15076694 | 0.83 | SIRT2 (0.72) | MEN1KMT2AALDH1A1NPSR1SIRT2 | |
| SCHEMBL19457367 | 0.83 | EPHX2 (0.55) | MEN1KMT2AALDH1A1NPSR1LMNA | |
| SCHEMBL2856989 | 0.83 | PKLR (0.57) | ALDH1A1NPSR1LMNAAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107148417-B | Benzazepine sulfonamide compounds | 豪夫迈·罗氏有限公司 | 2020-09-08 | — | — | CN | disclosed |
| EP-3233835-B1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2019-01-23 | — | — | EP | disclosed |
| EP-3233835-B1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2019-01-23 | — | — | EP | disclosed |
| US-9890124-B2 | Benzazepine sulfonamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2018-02-13 | — | — | US | disclosed |
| US-9890124-B2 | Benzazepine sulfonamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2018-02-13 | — | — | US | disclosed |
| US-9890124-B2 | Benzazepine sulfonamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2018-02-13 | — | — | US | disclosed |
| US-20170275253-A1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2017-09-28 | — | — | US | disclosed |
| US-20170275253-A1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2017-09-28 | — | — | US | disclosed |
| US-20170275253-A1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2017-09-28 | — | — | US | disclosed |
| WO-2016096778-A1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170275253-A1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | TLR8, TLR7, TLR5 | MBTD1 1620/4885L3MBTL3 1783/4885MEN1 3548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.