Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.68 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | GPR183 | P32249 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | IL1RN | P18510 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17860988 | 0.91 | MBTD1 (0.61) | MBTD1L3MBTL3KMT2AMEN1ALDH1A1 | |
| SCHEMBL17843469 | 0.91 | MBTD1 (0.61) | MBTD1L3MBTL3KMT2AMEN1ALDH1A1 | |
| SCHEMBL17861034 | 0.91 | MBTD1 (0.61) | MBTD1L3MBTL3KMT2AMEN1ALDH1A1 | |
| SCHEMBL3387440 | 0.86 | MBTD1 (0.70) | MBTD1L3MBTL3KMT2AMEN1ALDH1A1 | |
| SCHEMBL17843460 | 0.84 | MBTD1 (0.56) | MBTD1L3MBTL3KMT2AMEN1ALDH1A1 | |
| SCHEMBL3711656 | 0.83 | MBTD1 (0.59) | MBTD1L3MBTL3KMT2AMEN1ALDH1A1 | |
| SCHEMBL17843466 | 0.83 | MBTD1 (0.59) | MBTD1L3MBTL3KMT2AMEN1ALDH1A1 | |
| SCHEMBL17861096 | 0.83 | MBTD1 (0.59) | MBTD1L3MBTL3KMT2AMEN1ALDH1A1 | |
| SCHEMBL263317 | 0.82 | MBTD1 (0.73) | MBTD1L3MBTL3KMT2AMEN1ALDH1A1 | |
| SCHEMBL3384758 | 0.82 | MBTD1 (0.68) | MBTD1L3MBTL3KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107148417-B | Benzazepine sulfonamide compounds | 豪夫迈·罗氏有限公司 | 2020-09-08 | — | — | CN | disclosed |
| EP-3233835-B1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2019-01-23 | — | — | EP | disclosed |
| EP-3233835-B1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2019-01-23 | — | — | EP | disclosed |
| US-9890124-B2 | Benzazepine sulfonamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2018-02-13 | — | — | US | disclosed |
| US-9890124-B2 | Benzazepine sulfonamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2018-02-13 | — | — | US | disclosed |
| US-9890124-B2 | Benzazepine sulfonamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2018-02-13 | — | — | US | disclosed |
| EP-3233835-A1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2017-10-25 | — | — | EP | disclosed |
| US-20170275253-A1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2017-09-28 | — | — | US | disclosed |
| US-20170275253-A1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2017-09-28 | — | — | US | disclosed |
| US-20170275253-A1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2017-09-28 | — | — | US | disclosed |
| WO-2016096778-A1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-06-23 | — | — | WO | disclosed |
| WO-2016096778-A1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-06-23 | — | — | WO | disclosed |
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |
| WO-2009133127-A1 | FUSED BICYCLIC COMPOUNDS AND USE THEREOF AS PI3K INHIBITORS | MERCK SERONO S.A. (CH) | 2009-11-05 | — | — | WO | disclosed |
| WO-2009133127-A1 | FUSED BICYCLIC COMPOUNDS AND USE THEREOF AS PI3K INHIBITORS | MERCK SERONO S.A. (CH) | 2009-11-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170275253-A1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | TLR8, TLR7, TLR5 | MBTD1 1620/4885L3MBTL3 1783/4885KMT2A 752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.