Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1547778 | 0.80 | ALDH1A1 (0.49) | KDM4EALDH1A1MAPTABCG2PARP1 | |
| SCHEMBL1548445 | 0.76 | KDM4E (0.52) | KDM4EALDH1A1MAPTHSD17B10CA12 | |
| SCHEMBL29613830 | 0.75 | ALDH1A1 (0.56) | KDM4EALDH1A1MAPTABCG2PARP1 | |
| SCHEMBL1030218 | 0.74 | CA12 (0.65) | KDM4EALDH1A1MAPTPARP1HSD17B10 | |
| SCHEMBL28316098 | 0.73 | KDM4E (0.44) | KDM4EALDH1A1MAPTABCG2PARP1 | |
| SCHEMBL6008353 | 0.72 | ABCG2 (0.65) | KDM4EALDH1A1MAPTABCG2PARP1 | |
| SCHEMBL349002 | 0.72 | CA12 (0.57) | KDM4EALDH1A1MAPTPARP1CA12 | |
| SCHEMBL30149138 | 0.71 | ALDH1A1 (0.52) | KDM4EALDH1A1MAPTABCG2PARP1 | |
| SCHEMBL23885269 | 0.71 | KDM4E (0.45) | KDM4EALDH1A1MAPTABCG2PARP1 | |
| SCHEMBL30254396 | 0.71 | KDM4E (0.45) | KDM4EALDH1A1MAPTABCG2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2314575-B1 | NOVEL INDOLE DERIVATIVE HAVING CARBAMOYL GROUP, UREIDO GROUP AND SUBSTITUTED OXY GROUP | SANTEN PHARMACEUTICAL CO LTD (JP) | 2013-06-19 | — | — | EP | disclosed |
| EP-2314575-B1 | NOVEL INDOLE DERIVATIVE HAVING CARBAMOYL GROUP, UREIDO GROUP AND SUBSTITUTED OXY GROUP | SANTEN PHARMACEUTICAL CO LTD (JP) | 2013-06-19 | — | — | EP | disclosed |
| US-8445529-B2 | Indole derivative having, carbamoyl group, ureido group and substituted oxy group | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2013-05-21 | — | — | US | disclosed |
| US-8445529-B2 | Indole derivative having, carbamoyl group, ureido group and substituted oxy group | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2013-05-21 | — | — | US | disclosed |
| US-8445529-B2 | Indole derivative having, carbamoyl group, ureido group and substituted oxy group | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2013-05-21 | — | — | US | disclosed |
| US-20110124668-A1 | NOVEL INDOLE DERIVATIVE HAVING, CARBAMOYL GROUP, UREIDO GROUP AND SUBSTITUTED OXY GROUP | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2011-05-26 | — | — | US | disclosed |
| US-20110124668-A1 | NOVEL INDOLE DERIVATIVE HAVING, CARBAMOYL GROUP, UREIDO GROUP AND SUBSTITUTED OXY GROUP | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2011-05-26 | — | — | US | disclosed |
| US-20110124668-A1 | NOVEL INDOLE DERIVATIVE HAVING, CARBAMOYL GROUP, UREIDO GROUP AND SUBSTITUTED OXY GROUP | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2011-05-26 | — | — | US | disclosed |
| EP-2314575-A1 | NOVEL INDOLE DERIVATIVE HAVING CARBAMOYL GROUP, UREIDE GROUP AND SUBSTITUTED OXY GROUP | Santen Pharmaceutical Co., Ltd (JP) | 2011-04-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110124668-A1 | NOVEL INDOLE DERIVATIVE HAVING, CARBAMOYL GROUP, UREIDO GROUP AND SUBSTITUTED OXY GROUP | IKBKB, CHUK, RELA | KDM4E 406/4885ALDH1A1 2063/4885MAPT 4358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.