Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.57 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL142549 | 0.76 | KDM4E (0.54) | DPP4CYP1A1CYP1A2CYP1B1ADORA3 | |
| SCHEMBL338452 | 0.75 | CLK4 (0.64) | CYP1A1CYP1A2CYP1B1ADORA3ALDH1A1 | |
| SCHEMBL110083 | 0.75 | KDM4E (0.50) | DPP4ADORA3ALDH1A1ADORA1KDM4E | |
| SCHEMBL11468071 | 0.75 | ADORA2A (0.49) | DPP4CYP1A1CYP1A2CYP1B1ALDH1A1 | |
| SCHEMBL3418789 | 0.74 | DYRK1A (0.58) | CYP1A1CYP1A2CYP1B1ALDH1A1ADORA1 | |
| SCHEMBL669785 | 0.74 | DYRK1A (0.58) | CYP1A1CYP1A2CYP1B1ADORA3ALDH1A1 | |
| SCHEMBL10508211 | 0.74 | ALDH1A1 (0.60) | ALDH1A1ADORA1HPGDKDM4ELMNA | |
| SCHEMBL15896952 | 0.73 | CLK4 (0.61) | CYP1A1CYP1A2CYP1B1ADORA3ALDH1A1 | |
| SCHEMBL2876553 | 0.73 | CLK4 (0.61) | CYP1A1CYP1A2CYP1B1ADORA3ALDH1A1 | |
| SCHEMBL10375260 | 0.73 | SMN1; SMN2 (0.56) | DPP4ADORA3ALDH1A1ADORA1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058988-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058988-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | JAK2, JAK1, JAK3 | DPP4 2042/4885CYP1A1 865/4885CYP1A2 1040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.