SCHEMBL338452

SCHEMBL338452

COc1ccc(-c2nc(-c3ccc(OC)cc3)nc(-c3ccc(OC)cc3)n2)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CLK4 Q9HAZ1 1/20 0.64
MAPT P10636 3/20 0.61
KDM4E B2RXH2 1/20 0.61
TP53 P04637 1/20 0.61
CA12 O43570 1/20 0.58
CA1 P00915 1/20 0.58
CA2 P00918 1/20 0.58
CA7 P43166 1/20 0.58
CA9 Q16790 1/20 0.58
CA14 Q9ULX7 1/20 0.58
XDH P47989 1/20 0.53
NPC1 O15118 5/20 0.53
RAB9A P51151 3/20 0.53
SMN1; SMN2 Q16637 2/20 0.53
NPSR1 Q6W5P4 1/20 0.53
S1PR1 P21453 1/20 0.53
NR1H4 Q96RI1 1/20 0.53
CYP1A1 P04798 1/20 0.53
CYP1A2 P05177 1/20 0.53
CYP1B1 Q16678 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15896952 0.97 CLK4 (0.61) CLK4MAPTKDM4ETP53CA12
SCHEMBL2876553 0.97 CLK4 (0.61) CLK4MAPTKDM4ETP53CA12
SCHEMBL7646098 0.91 S1PR1 (0.66) CLK4MAPTKDM4ENPC1RAB9A
SCHEMBL14264452 0.91 MAPT (0.66) CLK4MAPTKDM4ETP53CA12
SCHEMBL19175445 0.91 MAPT (0.66) CLK4MAPTKDM4ETP53CA12
SCHEMBL19175444 0.89 CLK4 (0.53) CLK4MAPTKDM4ETP53CA12
SCHEMBL15805573 0.89 ESR2 (0.72) CLK4MAPTKDM4ETP53NPC1
SCHEMBL3418789 0.89 DYRK1A (0.58) CLK4MAPTKDM4ETP53NPC1
SCHEMBL7801135 0.89 CHRNA7 (0.55) CLK4MAPTKDM4ETP53CA12
SCHEMBL19275034 0.87 CLK4 (0.52) CLK4MAPTKDM4ETP53CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102448429-B Benzylidene malonates 巴斯夫欧洲公司 2018-03-06 CN claimed
EP-1768644-B1 LIGHT PROTECTING-EFFECTIVE COSMETIC OR DERMATOLOGICAL PREPARATIONS CIBA HOLDING INC (CH) 2009-02-18 EP claimed
EP-3769624-B1 ENHANCING THE ANTIMICROBIAL ACTIVITY OF BIOCIDES WITH POLYMERS BASF SE (DE) 2024-10-30 EP disclosed
CN-112074736-B UV filter composition, method for the production thereof and use thereof 巴斯夫欧洲公司 2024-10-01 CN disclosed
US-20240108556-A1 SCAR TREATMENT COMPOSITION TOPIX PHARMACEUTICALS, INC. 2024-04-04 US disclosed
US-20240075112-A1 SCAR TREATMENT COMPOSITION TOPIX PHARMACEUTICALS, INC. 2024-03-07 US disclosed
US-11793742-B2 Mixtures of cosmetic UV absorbers BASF SE (DE) 2023-10-24 US disclosed
CN-116782923-A Scar treatment composition 塔普克斯制药公司 2023-09-19 CN disclosed
CN-116710081-A Scar treatment composition 塔普克斯制药公司 2023-09-05 CN disclosed
US-11666050-B2 Enhancing the antimicrobial activity of biocides with polymers BASF SE (DE) 2023-06-06 US disclosed
US-11647746-B2 Enhancing the antimicrobial activity of biocides with polymers BASF SE (DE) 2023-05-16 US disclosed
US-20070104662-A1 Ultraviolet ray absorbing composite powder IWASE COSFA CO., LTD. (JP) 2007-05-10 US disclosed
US-7192453-B2 Method of coloring keratin-containing fibres using diazonium salts CIBA SPECIALTY CHEMICALS CORPORATION (US) 2007-03-20 US disclosed
US-20060162095-A1 Method of colouring porous material CIBA SPECIALTY CHEMICALS CORP. 2006-07-27 US disclosed
US-20050251932-A1 Method of colouring porous material CIBA SPECIALTY CHEMICALS CORP. 2005-11-17 US disclosed
CN-1678285-A Dyeing method for porous material CIBA SC HOLDING AG (CH) 2005-10-05 CN disclosed
CN-1678284-A Dyeing method for porous material CIBA SC HOLDING AG (CH) 2005-10-05 CN disclosed
US-20050129632-A1 Uv absorber compositions comprising a hydroxyphenyltriazine compound CIBA SPECIALTY CHEMICALS CORP. 2005-06-16 US disclosed
US-20050000034-A1 Yellow cationic dyes for dyeing of organic material CIBA SPECIALTY CHEMICALS CORPORATION 2005-01-06 US disclosed
US-3932402-A Preparation of sym-triazines by trimerization of nitriles in trifluoromethanesulfonic acid PHILLIPS PETROLEUM COMPANY (US) 1976-01-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060162095-A1 Method of colouring porous material ACR, HLA-C, TYR CLK4 2482/4885MAPT 2284/4885KDM4E 2481/4885
US-20050000034-A1 Yellow cationic dyes for dyeing of organic material KRT18, PYCR1, CYC1 CLK4 2103/4885MAPT 955/4885KDM4E 1285/4885
US-20240108556-A1 SCAR TREATMENT COMPOSITION MMP1, MMP8, PLAT CLK4 4661/4885MAPT 2871/4885KDM4E 2616/4885
US-20050129632-A1 Uv absorber compositions comprising a hydroxyphenyltriazine compound C1R, C5, C3AR1 CLK4 1948/4885MAPT 3054/4885KDM4E 2003/4885
US-20050251932-A1 Method of colouring porous material TYR, SDHB, CYCS CLK4 3879/4885MAPT 2909/4885KDM4E 1861/4885
US-11647746-B2 Enhancing the antimicrobial activity of biocides with polymers CAT, AOC1, DDT CLK4 2110/4885MAPT 4500/4885KDM4E 2071/4885
US-20070104662-A1 Ultraviolet ray absorbing composite powder XRCC5, XRCC6, ERCC1 CLK4 3826/4885MAPT 485/4885KDM4E 2674/4885
US-20240075112-A1 SCAR TREATMENT COMPOSITION MMP1, MMP8, MMP2 CLK4 4675/4885MAPT 2448/4885KDM4E 1907/4885
US-11666050-B2 Enhancing the antimicrobial activity of biocides with polymers CAT, AOC1, DDT CLK4 2110/4885MAPT 4500/4885KDM4E 2071/4885
US-11793742-B2 Mixtures of cosmetic UV absorbers BTD, TMSB10, TH CLK4 2932/4885MAPT 2781/4885KDM4E 1877/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.