Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | WDR5 | P61964 | 1/20 | 0.44 |
| ▸ | TNKS | O95271 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | MELK | Q14680 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15603570 | 0.80 | HDAC1 (0.53) | NOTUMALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL17809581 | 0.78 | WDR5 (0.50) | NOTUMALDH1A1MEN1GAAMAPT | |
| SCHEMBL15603591 | 0.75 | HDAC1 (0.49) | NOTUMALDH1A1MEN1GAAMAPT | |
| SCHEMBL15603587 | 0.75 | HDAC1 (0.51) | NOTUMALDH1A1KMT2AHDAC1HDAC8 | |
| SCHEMBL15603589 | 0.75 | HDAC1 (0.48) | NOTUMALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL17809777 | 0.75 | CYP11B2 (0.48) | NOTUMALDH1A1MEN1GAAMAPT | |
| SCHEMBL17809564 | 0.75 | WDR5 (0.49) | NOTUMALDH1A1MEN1GAAMAPT | |
| SCHEMBL15603593 | 0.74 | HDAC1 (0.50) | NOTUMMAPTHDAC1HDAC8HDAC6 | |
| SCHEMBL17809621 | 0.74 | ALDH1A1 (0.50) | NOTUMALDH1A1MEN1GAAMAPT | |
| SCHEMBL17809559 | 0.74 | WDR5 (0.51) | NOTUMALDH1A1MEN1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016086200-A9 | 4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS | GENENTECH, INC. (US) | 2016-06-23 | — | — | WO | disclosed |