Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.47 |
| ▸ | RXRB | P28702 | 2/20 | 0.47 |
| ▸ | KIF11 | P52732 | 2/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | PTPN5 | P54829 | 3/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL547993 | 0.86 | RXRA (0.51) | RXRARXRBKIF11NR4A2KCNH2 | |
| SCHEMBL548600 | 0.86 | KIF11 (0.50) | RXRARXRBKIF11NR4A2KCNH2 | |
| SCHEMBL23959429 | 0.85 | KIF11 (0.61) | RXRARXRBKIF11PTPN5PTPN1 | |
| SCHEMBL548430 | 0.84 | RXRA (0.53) | RXRARXRBKIF11NR4A2KCNH2 | |
| SCHEMBL17806543 | 0.83 | RXRA (0.57) | RXRARXRBKIF11NR4A2KCNH2 | |
| SCHEMBL17795033 | 0.83 | PTPN5 (0.57) | RXRARXRBKIF11NR4A2KCNH2 | |
| SCHEMBL13694196 | 0.83 | RXRA (0.53) | RXRARXRBKIF11NR4A2KCNH2 | |
| SCHEMBL17806549 | 0.80 | KIF11 (0.60) | RXRARXRBKIF11NR4A2KCNH2 | |
| SCHEMBL547878 | 0.80 | RXRB (0.49) | RXRARXRBKIF11NR4A2KCNH2 | |
| SCHEMBL13816684 | 0.80 | RXRA (0.46) | RXRARXRBKIF11PTPN5PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016086200-A9 | 4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS | GENENTECH, INC. (US) | 2016-06-23 | — | — | WO | disclosed |