Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17529471 | 1.00 | PDE3B (0.47) | PDE3BPDE3AL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL3370500 | 0.86 | L3MBTL1 (0.48) | L3MBTL1SMN1; SMN2MAPTHPGDNPC1 | |
| SCHEMBL5843168 | 0.86 | THRA (0.43) | SMN1; SMN2SMPD1 | |
| SCHEMBL21823607 | 0.84 | LMNA (0.49) | PDE3BPDE3AL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL31096332 | 0.84 | LMNA (0.49) | PDE3BPDE3AL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL15691067 | 0.82 | PDE3B (0.48) | PDE3BPDE3AL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL15839257 | 0.81 | L3MBTL1 (0.47) | PDE3BPDE3AL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL18466878 | 0.81 | PDE3B (0.43) | PDE3BPDE3AL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL29622968 | 0.81 | CYP1A2 (0.45) | L3MBTL1SMN1; SMN2MAPTHPGDNPC1 | |
| SCHEMBL7739532 | 0.81 | CYP1A2 (0.45) | L3MBTL1SMN1; SMN2MAPTHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100391-A1 | 2-PHENETHENYLTETRAHYDRO ISOQUINOLINES USEFUL AS ANTI-HIV COMPOUNDS | Prosetta Antiviral, Inc. (US) | 2016-06-23 | — | — | WO | disclosed |