Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.42 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19079671 | 0.81 | GABRA1 (0.43) | KIF11MAPTSMN1; SMN2L3MBTL1GABRA1 | |
| SCHEMBL13073461 | 0.81 | KIF11 (0.50) | KIF11MAPTSMN1; SMN2L3MBTL1GABRA1 | |
| SCHEMBL17600536 | 0.80 | KIF11 (0.43) | KIF11MAPTL3MBTL1GABRA1GABRB2 | |
| SCHEMBL13259618 | 0.80 | GABRA1 (0.56) | KIF11MAPTGABRA1GABRB2NOS1 | |
| SCHEMBL15355926 | 0.80 | HDAC4 (0.48) | KIF11MAPTGABRA1GABRB2HPGD | |
| SCHEMBL26598413 | 0.79 | KIF11 (0.49) | KIF11GABRA1GABRB2DUSP3GABRG2 | |
| SCHEMBL2380170 | 0.79 | KIF11 (0.51) | KIF11SMN1; SMN2NOS1HPGDALDH1A1 | |
| SCHEMBL19090382 | 0.78 | MAPT (0.44) | MAPTSMN1; SMN2L3MBTL1PTPN1GSK3B | |
| SCHEMBL19733924 | 0.78 | KIF11 (0.48) | KIF11GABRA1GABRB2DUSP3GABRG2 | |
| SCHEMBL14655025 | 0.78 | KIF11 (0.51) | KIF11SMN1; SMN2HPGDHTTPDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170190717-A1 | Compounds and Methods for Inhibition of Hedgehog Signaling and Phosphodiesterase | VANDERBILT UNIVERSITY | 2017-07-06 | — | — | US | disclosed |
| WO-2016096897-A1 | COSMETIC METHOD FOR CONTROLLING ODORS | L'OREAL (FR) | 2016-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190717-A1 | Compounds and Methods for Inhibition of Hedgehog Signaling and Phosphodiesterase | PDE4A, PDE4B, PDE7A | KIF11 3346/4885MAPT 4761/4885SMN1; SMN2 4025/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.