Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | RIOK2 | Q9BVS4 | 3/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | RGS12 | O14924 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17840843 | 0.86 | KDR (0.39) | METPIK3C3TGFBR1ADORA3NR3C2 | |
| SCHEMBL17865341 | 0.83 | GSK3A (0.39) | GAAPIK3C3L3MBTL1TGFBR1ACACB | |
| SCHEMBL17840730 | 0.81 | MET (0.42) | METPIK3C3TGFBR1ADORA3AAK1 | |
| SCHEMBL17863795 | 0.76 | PIK3C3 (0.49) | PIK3C3L3MBTL1TGFBR1 | |
| SCHEMBL17840896 | 0.73 | AAK1 (0.43) | METPIK3C3L3MBTL1ACACBAAK1 | |
| SCHEMBL17840786 | 0.72 | PIK3C3 (0.38) | PIK3C3L3MBTL1TGFBR1 | |
| SCHEMBL17840596 | 0.72 | PIK3C3 (0.41) | PIK3C3L3MBTL1TGFBR1 | |
| SCHEMBL17840748 | 0.71 | PTK2 (0.40) | PIK3C3L3MBTL1TGFBR1 | |
| SCHEMBL17840555 | 0.71 | PIK3C3 (0.38) | PIK3C3SMN1; SMN2L3MBTL1 | |
| SCHEMBL19133730 | 0.71 | ACACB (0.43) | PIK3C3ALDH1A1L3MBTL1TGFBR1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160176871-A1 | TGF BETA R ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY | 2016-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160176871-A1 | TGF BETA R ANTAGONISTS | TGFBR2, TGFBR1, TGFB1 | MET 218/4885GAA 3046/4885PIK3C3 2608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.