⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6554973 | 0.74 | — | — | |
| SCHEMBL6304946 | 0.60 | ALDH1A1 (0.53) | — | |
| SCHEMBL27551614 | 0.56 | — | — | |
| SCHEMBL3226776 | 0.53 | — | — | |
| Bicarbonate SCHEMBL10433540 | 0.47 | MAPT (0.61) | — | |
| Bicarbonate SCHEMBL11010145 | 0.47 | MAPT (0.61) | — | |
| Bicarbonate SCHEMBL5708571 | 0.47 | CYP1A2 (0.57) | — | |
| Bicarbonate SCHEMBL4615338 | 0.47 | CYP1A2 (0.57) | — | |
| Carbamic Acid SCHEMBL21315591 | 0.46 | CYP1A2 (0.55) | — | |
| Benzene SCHEMBL9228633 | 0.43 | LMNA (0.67) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10927097-B2 | Indole compound as inhibitor of necrosis | LG CHEM, LTD. (KR) | 2021-02-23 | — | — | US | claimed |
| EP-3037418-B1 | INDOLE COMPOUND AS INHIBITOR OF NECROSIS | LG CHEMICAL LTD (KR) | 2019-10-02 | — | — | EP | claimed |
| CN-105636956-B | Indole compounds as inhibitors of cellular necrosis | 株式会社LG化学 | 2019-07-09 | — | — | CN | claimed |
| US-20160200709-A1 | INDOLE COMPOUND AS INHIBITOR OF NECROSIS | LG LIFE SCIENCES LTD. (KR) | 2016-07-14 | — | — | US | claimed |
| EP-3037418-A1 | INDOLE COMPOUND AS INHIBITOR OF NECROSIS | LG Life Sciences Ltd. (KR) | 2016-06-29 | — | — | EP | claimed |
| CN-105636956-A | Indole compound as inhibitor of necrosis | LG LIFE SCIENCES LTD | 2016-06-01 | — | — | CN | claimed |
| US-10927097-B2 | Indole compound as inhibitor of necrosis | LG CHEM, LTD. (KR) | 2021-02-23 | — | — | US | disclosed |
| EP-3037418-B1 | INDOLE COMPOUND AS INHIBITOR OF NECROSIS | LG CHEMICAL LTD (KR) | 2019-10-02 | — | — | EP | disclosed |
| CN-105636956-B | Indole compounds as inhibitors of cellular necrosis | 株式会社LG化学 | 2019-07-09 | — | — | CN | disclosed |
| US-20160200709-A1 | INDOLE COMPOUND AS INHIBITOR OF NECROSIS | LG LIFE SCIENCES LTD. (KR) | 2016-07-14 | — | — | US | disclosed |
| EP-3037418-A1 | INDOLE COMPOUND AS INHIBITOR OF NECROSIS | LG Life Sciences Ltd. (KR) | 2016-06-29 | — | — | EP | disclosed |
| CN-105636956-A | Indole compound as inhibitor of necrosis | LG LIFE SCIENCES LTD | 2016-06-01 | — | — | CN | disclosed |