Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 3/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | UBA3 | Q8TBC4 | 2/20 | 0.49 |
| ▸ | UBA6 | A0AVT1 | 2/20 | 0.49 |
| ▸ | GRK5 | P34947 | 1/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.49 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.49 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.49 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL191796 | 0.87 | NAE1 (0.63) | NAE1CA2UBA3UBA6GRK5 | |
| SCHEMBL17865955 | 0.85 | NAE1 (0.51) | NAE1CA2UBA3UBA6GRK5 | |
| SCHEMBL17865943 | 0.85 | KDM4E (0.47) | NAE1CA2UBA3UBA6GRK5 | |
| SCHEMBL5456441 | 0.84 | KDM4E (0.52) | UBA6KDM4ETP53LMNAMAPT | |
| SCHEMBL17865972 | 0.82 | NAE1 (0.51) | NAE1CA2UBA3UBA6GRK5 | |
| SCHEMBL17865916 | 0.82 | NAE1 (0.51) | NAE1CA2UBA3UBA6GRK5 | |
| SCHEMBL10004854 | 0.81 | NAE1 (0.52) | NAE1CA2UBA3UBA6GRK5 | |
| SCHEMBL17865962 | 0.81 | NAE1 (0.49) | NAE1CA2UBA3UBA6GRK5 | |
| SCHEMBL17865957 | 0.80 | NAE1 (0.46) | NAE1CA2UBA3UBA6GRK5 | |
| SCHEMBL17865920 | 0.80 | METTL3 (0.55) | NAE1CA2UBA3UBA6GRK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402334-B1 | Inhibitors of E1 Activating Enzymes | MILLENNIUM PHARM INC (US) | 2016-06-29 | — | — | EP | claimed |