Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | USP2 | O75604 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17866004 | 0.88 | AURKA (0.42) | ADORA3ADORA2AADORA1AURKARPS6KB1 | |
| SCHEMBL17865956 | 0.86 | NAE1 (0.43) | KDM4ELMNATP53MAPTSMN1; SMN2 | |
| SCHEMBL17865967 | 0.86 | AURKA (0.42) | LMNAAURKARPS6KB1NAE1CA2 | |
| SCHEMBL17865941 | 0.85 | NAE1 (0.49) | KDM4ELMNATP53MAPTMAPK1 | |
| SCHEMBL5456441 | 0.84 | KDM4E (0.52) | KDM4ELMNATP53MAPTMAPK1 | |
| SCHEMBL191796 | 0.82 | NAE1 (0.63) | KDM4ELMNATP53MAPTAURKA | |
| SCHEMBL17865958 | 0.82 | TP53 (0.45) | LMNATP53MAPTMAPK1POLB | |
| SCHEMBL17865979 | 0.81 | METTL3 (0.40) | LMNATP53POLBADORA3NAE1 | |
| SCHEMBL10004855 | 0.81 | ADK (0.47) | KDM4EMAPTPOLBCYP3A4CYP2C19 | |
| SCHEMBL17865976 | 0.80 | CCNA2 (0.44) | ADORA3AURKARPS6KB1NAE1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402334-B1 | Inhibitors of E1 Activating Enzymes | MILLENNIUM PHARM INC (US) | 2016-06-29 | — | — | EP | claimed |