Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PDE5A | O76074 | 10/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NAE1 | Q13564 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL192776 | 0.87 | NAE1 (0.57) | KDM4EMAPTMAPK1L3MBTL1PDE5A | |
| SCHEMBL17865975 | 0.86 | NAE1 (0.45) | MEN1KMT2AAURKARPS6KB1NAE1 | |
| SCHEMBL17865944 | 0.85 | PDE5A (0.49) | KDM4EMAPTMAPK1L3MBTL1PDE5A | |
| SCHEMBL17865957 | 0.85 | NAE1 (0.46) | KDM4EMAPTMAPK1ALDH1A1TSHR | |
| SCHEMBL17865955 | 0.85 | NAE1 (0.51) | KDM4EMAPK1ALDH1A1TSHRHSD17B10 | |
| SCHEMBL17865920 | 0.84 | METTL3 (0.55) | MAPTMAPK1NAE1CA2GRK5 | |
| SCHEMBL17866025 | 0.84 | KDM4E (0.53) | KDM4EMAPTMAPK1L3MBTL1PDE5A | |
| SCHEMBL17865916 | 0.81 | NAE1 (0.51) | NAE1CA2GRK5CSNK1A1UBA6 | |
| SCHEMBL17865925 | 0.80 | NAE1 (0.44) | NAE1CA2GRK5CSNK1A1UBA6 | |
| SCHEMBL17865972 | 0.80 | NAE1 (0.51) | NAE1CA2GRK5CSNK1A1UBA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402334-B1 | Inhibitors of E1 Activating Enzymes | MILLENNIUM PHARM INC (US) | 2016-06-29 | — | — | EP | claimed |