Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 14/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17865976 | 0.86 | CCNA2 (0.44) | AURKARPS6KB1 | |
| SCHEMBL17865956 | 0.86 | NAE1 (0.43) | KDM4EMAPTALDH1A1TSHRHSD17B10 | |
| SCHEMBL17865942 | 0.85 | KDM4E (0.48) | PDE5AKDM4EMAPTALDH1A1TSHR | |
| SCHEMBL17865921 | 0.85 | METTL3 (0.54) | PDE5AMAPTMAPK1 | |
| SCHEMBL17865958 | 0.85 | TP53 (0.45) | MAPTRXFP1MAPK1EGFR | |
| SCHEMBL17866025 | 0.84 | KDM4E (0.53) | PDE5AKDM4EMAPTALDH1A1TSHR | |
| SCHEMBL17865924 | 0.82 | UBA6 (0.38) | — | |
| SCHEMBL192776 | 0.82 | NAE1 (0.57) | PDE5AKDM4EMAPTALDH1A1TSHR | |
| SCHEMBL17865917 | 0.81 | UBA6 (0.42) | — | |
| SCHEMBL17865973 | 0.81 | UBA6 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402334-B1 | Inhibitors of E1 Activating Enzymes | MILLENNIUM PHARM INC (US) | 2016-06-29 | — | — | EP | claimed |