SCHEMBL27739697

SCHEMBL27739697

Cc1ncnc2c1ccn2C1C[CH]C(O)C1

nearest known ligand 0.43

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PRMT5 O14744 20/20 0.43
WDR77 Q9BQA1 17/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16414565 1.00 PRMT5 (0.43) PRMT5WDR77
SCHEMBL18727734 0.84 ADK (0.48) PRMT5WDR77
SCHEMBL17866020 0.77 UBA6 (0.43) PRMT5WDR77
SCHEMBL19667421 0.77 PRMT5 (0.42) PRMT5WDR77
SCHEMBL25047393 0.76 PRMT5 (0.40) PRMT5WDR77
SCHEMBL25048671 0.75 UBA6 (0.42) PRMT5WDR77
SCHEMBL10186224 0.75 UBA6 (0.42) PRMT5WDR77
SCHEMBL17865952 0.75 KDM4E (0.48) PRMT5
SCHEMBL17865990 0.74 SLC29A1 (0.57)
SCHEMBL13170707 0.73 UBA6 (0.42) PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103288835-A Inhibitors of E1 activating enzyme MILLENNIUM PHARM INC 2013-09-11 CN disclosed
CN-101379061-A E1 activating enzyme inhibitor MILLENNIUM PHARM INC (US) 2009-03-04 CN disclosed