Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UBA6 | A0AVT1 | 5/20 | 0.38 |
| ▸ | NAE1 | Q13564 | 4/20 | 0.37 |
| ▸ | UBA3 | Q8TBC4 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | GRK5 | P34947 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.37 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.37 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 6/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17866000 | 0.85 | UBA6 (0.37) | UBA6NAE1UBA3CA2GRK5 | |
| SCHEMBL17865956 | 0.84 | NAE1 (0.43) | UBA6NAE1UBA3CA2GRK5 | |
| SCHEMBL17865966 | 0.84 | SLC29A1 (0.51) | SLC29A1ALDH1A1 | |
| SCHEMBL17865978 | 0.81 | NAE1 (0.46) | UBA6NAE1UBA3CA2GRK5 | |
| SCHEMBL10004855 | 0.80 | ADK (0.47) | UBA6NAE1UBA3CA2GRK5 | |
| SCHEMBL17866054 | 0.80 | UBA6 (0.41) | UBA6NAE1UBA3CA2GRK5 | |
| SCHEMBL17865973 | 0.79 | UBA6 (0.42) | UBA6NAE1UBA3CA2GRK5 | |
| SCHEMBL192481 | 0.78 | NAE1 (0.60) | UBA6NAE1UBA3CA2GRK5 | |
| SCHEMBL17865921 | 0.77 | METTL3 (0.54) | NAE1CA2GRK5CSNK1A1METTL3 | |
| SCHEMBL17865958 | 0.76 | TP53 (0.45) | UBA6NAE1UBA3CA2GRK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402334-B1 | Inhibitors of E1 Activating Enzymes | MILLENNIUM PHARM INC (US) | 2016-06-29 | — | — | EP | claimed |