Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | LTK | P29376 | 1/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL191320 | 0.77 | CA2 (0.51) | LCKKDRABL1DAPK3MAP4K4 | |
| SCHEMBL14563560 | 0.68 | PRMT5 (0.36) | PRMT5WDR77 | |
| SCHEMBL17865973 | 0.67 | UBA6 (0.42) | CSNK1A1CA2PRMT5WDR77 | |
| SCHEMBL17865963 | 0.66 | UBA6 (0.41) | IGF1RCSNK1A1CA2PRMT5WDR77 | |
| SCHEMBL17865917 | 0.64 | UBA6 (0.42) | CSNK1A1CDK5ADKCA2PRMT5 | |
| SCHEMBL17865956 | 0.63 | NAE1 (0.43) | CSNK1A1ADKCA2PRMT5EGFR | |
| SCHEMBL17865924 | 0.62 | UBA6 (0.38) | CSNK1A1CA2PRMT5WDR77 | |
| SCHEMBL17866002 | 0.62 | NAE1 (0.41) | CSNK1A1CDK5ADKCA2PRMT5 | |
| SCHEMBL17865967 | 0.61 | AURKA (0.42) | CSNK1A1PTK2AURKBCA2TMEM97 | |
| SCHEMBL17865976 | 0.61 | CCNA2 (0.44) | ABL1CSNK1A1CDK5CA2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402334-B1 | Inhibitors of E1 Activating Enzymes | MILLENNIUM PHARM INC (US) | 2016-06-29 | — | — | EP | claimed |