Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | NAE1 | Q13564 | 3/20 | 0.40 |
| ▸ | UBA6 | A0AVT1 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | UBA3 | Q8TBC4 | 2/20 | 0.40 |
| ▸ | GRK5 | P34947 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.40 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.40 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17865959 | 0.89 | METTL3 (0.38) | NAE1UBA6CA2UBA3GRK5 | |
| SCHEMBL17866004 | 0.87 | AURKA (0.42) | AURKARPS6KB1AURKBNAE1UBA6 | |
| SCHEMBL17865943 | 0.86 | KDM4E (0.47) | AURKARPS6KB1NAE1UBA6CA2 | |
| SCHEMBL17865956 | 0.86 | NAE1 (0.43) | NAE1UBA6CA2UBA3GRK5 | |
| SCHEMBL17866057 | 0.83 | AURKA (0.45) | AURKARPS6KB1AURKBNAE1UBA6 | |
| SCHEMBL17865958 | 0.81 | TP53 (0.45) | NAE1UBA6CA2UBA3GRK5 | |
| SCHEMBL17865917 | 0.81 | UBA6 (0.42) | NAE1UBA6CA2UBA3GRK5 | |
| SCHEMBL193668 | 0.81 | NAE1 (0.62) | AURKARPS6KB1AURKBNAE1UBA6 | |
| SCHEMBL17865973 | 0.81 | UBA6 (0.42) | NAE1UBA6CA2UBA3GRK5 | |
| SCHEMBL17865979 | 0.81 | METTL3 (0.40) | NAE1UBA6CA2UBA3GRK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402334-B1 | Inhibitors of E1 Activating Enzymes | MILLENNIUM PHARM INC (US) | 2016-06-29 | — | — | EP | claimed |