Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 7/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2114642 | 0.86 | CNR1 (0.49) | CNR1PTGS2SCN5AKCNH2SCN2A | |
| SCHEMBL17866280 | 0.84 | CNR1 (0.46) | CNR1PTGS2SCN5AKCNH2SCN2A | |
| SCHEMBL17866251 | 0.84 | CNR1 (0.47) | CNR1PTGS2SCN5AKCNH2SCN2A | |
| SCHEMBL17866270 | 0.83 | CNR1 (0.45) | CNR1PTGS2SCN5AKCNH2SCN2A | |
| SCHEMBL17866268 | 0.83 | CNR1 (0.47) | CNR1PTGS2SCN5AKCNH2SCN2A | |
| SCHEMBL17866258 | 0.83 | CNR1 (0.47) | CNR1PTGS2SCN5AKCNH2SCN2A | |
| SCHEMBL17866284 | 0.83 | CNR1 (0.48) | CNR1PTGS2SCN5AKCNH2SCN2A | |
| SCHEMBL17866255 | 0.82 | CNR1 (0.46) | CNR1PTGS2SCN5AKCNH2SCN2A | |
| SCHEMBL17866263 | 0.82 | CNR1 (0.46) | CNR1PTGS2SCN5AKCNH2SCN2A | |
| SCHEMBL17866274 | 0.82 | CNR1 (0.44) | CNR1PTGS2SCN5AKCNH2SCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627637-B1 | N-PYRIDIN-3-YL OR N-PYRAZIN-2-YL CARBOXAMIDES | HOFFMANN LA ROCHE (CH) | 2016-06-29 | — | — | EP | claimed |