Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | GSK3A | P49840 | 3/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 3/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17866251 | 0.89 | CNR1 (0.47) | CNR1MAPTSMN1; SMN2NPSR1KCNH2 | |
| SCHEMBL17866268 | 0.88 | CNR1 (0.47) | CNR1MAPTSMN1; SMN2NPSR1KCNH2 | |
| SCHEMBL2114583 | 0.87 | CNR1 (0.51) | CNR1MAPTKCNH2SCN5ASCN2A | |
| SCHEMBL17866262 | 0.86 | CNR1 (0.47) | CNR1MAPTSMN1; SMN2NPSR1KCNH2 | |
| SCHEMBL17866284 | 0.86 | CNR1 (0.48) | CNR1MAPTSMN1; SMN2NPSR1KCNH2 | |
| SCHEMBL17866270 | 0.84 | CNR1 (0.45) | CNR1MAPTSMN1; SMN2NPSR1KCNH2 | |
| SCHEMBL17866283 | 0.84 | CNR1 (0.47) | CNR1MAPTSMN1; SMN2NPSR1KCNH2 | |
| SCHEMBL17866258 | 0.82 | CNR1 (0.47) | CNR1MAPTSMN1; SMN2NPSR1KCNH2 | |
| SCHEMBL17866261 | 0.82 | CNR1 (0.47) | CNR1MAPTSMN1; SMN2NPSR1KCNH2 | |
| SCHEMBL17866254 | 0.82 | MAPT (0.49) | CNR1MAPTSMN1; SMN2NPSR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627637-B1 | N-PYRIDIN-3-YL OR N-PYRAZIN-2-YL CARBOXAMIDES | HOFFMANN LA ROCHE (CH) | 2016-06-29 | — | — | EP | claimed |