Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Niacinamide SCHEMBL17868384 | 0.87 | LMNA (0.50) | HDAC1HDAC2LMNAHSD17B10TSHR | |
| Niacinamide SCHEMBL10685143 | 0.85 | MKNK1 (0.52) | HDAC1HDAC2LMNAHSD17B10TSHR | |
| Niacinamide SCHEMBL17868382 | 0.79 | MKNK1 (0.50) | LMNAHSD17B10TSHRMKNK1PRMT1 | |
| Niacinamide SCHEMBL11597779 | 0.76 | MKNK1 (0.47) | LMNAHSD17B10TSHRMKNK1CYP3A4 | |
| Niacinamide SCHEMBL11707347 | 0.74 | MKNK1 (0.45) | LMNAHSD17B10TSHRMKNK1TP53 | |
| Adenine SCHEMBL15700 | 0.74 | PI4KA (0.55) | LMNAMKNK1CYP3A4HTTBRD4 | |
| Adenine SCHEMBL22748487 | 0.74 | PI4KA (0.55) | LMNAMKNK1CYP3A4HTTBRD4 | |
| Adenine SCHEMBL2564210 | 0.74 | PI4KA (0.55) | LMNAMKNK1CYP3A4HTTBRD4 | |
| Adenine SCHEMBL23531102 | 0.73 | PI4KA (0.54) | LMNAMKNK1CYP3A4HTTBRD4 | |
| Adenine SCHEMBL7712108 | 0.73 | PI4KA (0.54) | LMNAMKNK1CYP3A4HTTBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10196412-B2 | Probe for imaging PARP-1 activity | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2019-02-05 | — | — | US | disclosed |
| US-20160185805-A1 | PROBE FOR IMAGING PARP-1 ACTIVITY | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2016-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10196412-B2 | Probe for imaging PARP-1 activity | PARP1, PARP2, PARP12 | HDAC1 73/4885HDAC2 165/4885LMNA 816/4885 |
| US-20160185805-A1 | PROBE FOR IMAGING PARP-1 ACTIVITY | PARP1, PARP2, PARP12 | HDAC1 73/4885HDAC2 165/4885LMNA 816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.