Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL10788717 | 1.00 | CA4 (0.42) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL14563794 | 0.95 | CA4 (0.39) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL15513824 | 0.95 | CA4 (0.39) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL17888511 | 0.94 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL9818436 | 0.94 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL175616 | 0.94 | — | — | |
| Bicarbonate SCHEMBL4705259 | 0.94 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL3037570 | 0.94 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL17746828 | 0.94 | — | — | |
| Bicarbonate SCHEMBL5680462 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016101979-A1 | FLAME-RETARDANT HEAVY METAL-FREE COATING FOR AN ELECTRICAL CABLE | PRYSMIAN S.P.A. (IT) | 2016-06-30 | — | — | WO | claimed |
| WO-2016101979-A1 | FLAME-RETARDANT HEAVY METAL-FREE COATING FOR AN ELECTRICAL CABLE | PRYSMIAN S.P.A. (IT) | 2016-06-30 | — | — | WO | disclosed |
| WO-2016101979-A1 | FLAME-RETARDANT HEAVY METAL-FREE COATING FOR AN ELECTRICAL CABLE | PRYSMIAN S.P.A. (IT) | 2016-06-30 | — | — | WO | disclosed |