SCHEMBL17870817

SCHEMBL17870817

CC(=O)NCCn1c(=O)c(Br)cn(CC(=O)O)c1=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK9 P50750 1/20 0.41
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
TP53 P04637 3/20 0.36
KDM4E B2RXH2 2/20 0.36
ALDH1A1 P00352 4/20 0.35
NPSR1 Q6W5P4 2/20 0.35
LMNA P02545 2/20 0.35
MAPT P10636 2/20 0.35
TSHR P16473 2/20 0.35
MAPK1 P28482 1/20 0.35
ADORA2B P29275 1/20 0.34
MTNR1A P48039 1/20 0.34
MTNR1B P49286 1/20 0.34
CYP3A4 P08684 2/20 0.34
CYP2C9 P11712 2/20 0.34
CYP2C19 P33261 2/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2D6 P10635 1/20 0.34
POLB P06746 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28644072 0.87 CDK9 (0.40) CDK9MEN1KMT2ATP53KDM4E
SCHEMBL21900253 0.83 CDK9 (0.37) CDK9MEN1KMT2AALDH1A1
SCHEMBL19873941 0.82 MEN1 (0.37) CDK9MEN1KMT2ATP53KDM4E
SCHEMBL17870821 0.82 CDK9 (0.42) CDK9KDM4EALDH1A1LMNAMAPT
SCHEMBL17870770 0.80 CDK9 (0.41) CDK9MEN1KMT2AKDM4EALDH1A1
SCHEMBL21900263 0.79 CDK9 (0.44) CDK9KMT2AKDM4EALDH1A1LMNA
SCHEMBL17870749 0.78 CDK9 (0.40) CDK9KMT2AKDM4EALDH1A1LMNA
SCHEMBL17870758 0.78 ALDH1A1 (0.41) CDK9MEN1KMT2AKDM4EALDH1A1
SCHEMBL17870781 0.77 CDK9 (0.39) CDK9KDM4EALDH1A1LMNAMAPT
SCHEMBL17870834 0.77 CDK9 (0.36) CDK9ADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3708566-B1 NOVEL HETEROCYCLIC COMPOUNDS AND THE USE THEREOF IN MEDICINE AND IN COSMETICS GALDERMA RES & DEV (FR) 2023-02-08 EP disclosed
EP-3708566-A1 NOVEL HETEROCYCLIC COMPOUNDS AND THE USE THEREOF IN MEDICINE AND IN COSMETICS Galderma Research & Development (FR) 2020-09-16 EP disclosed
EP-3237403-B1 NOVEL HETEROCYCLIC COMPOUNDS AND THE USE THEREOF IN MEDICINE AND IN COSMETICS GALDERMA RES & DEV (FR) 2020-05-06 EP disclosed
EP-3237403-A1 NOVEL HETEROCYCLIC COMPOUNDS AND THE USE THEREOF IN MEDICINE AND IN COSMETICS Galderma Research & Development (FR) 2017-11-01 EP disclosed
WO-2016102882-A1 NOVEL HETEROCYCLIC COMPOUNDS AND THE USE THEREOF IN MEDICINE AND IN COSMETICS GALDERMA RESEARCH & DEVELOPMENT (FR) 2016-06-30 WO disclosed