Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.50 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.48 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.48 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.48 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17871501 | 1.00 | MMP2 (0.51) | MMP2ADAMTS5GPR119SMARCA2SMARCA4 | |
| SCHEMBL38666126 | 0.87 | GPR119 (0.50) | GPR119SMARCA2SMARCA4PBRM1ABCB1 | |
| SCHEMBL29182666 | 0.87 | GPR119 (0.50) | GPR119SMARCA2SMARCA4PBRM1ABCB1 | |
| SCHEMBL11963206 | 0.87 | GPR119 (0.50) | GPR119SMARCA2SMARCA4PBRM1ABCB1 | |
| SCHEMBL11963207 | 0.87 | GPR119 (0.50) | GPR119SMARCA2SMARCA4PBRM1ABCB1 | |
| SCHEMBL17310244 | 0.86 | GPR119 (0.52) | GPR119SMARCA2SMARCA4PBRM1ABCB1 | |
| SCHEMBL17310245 | 0.86 | GPR119 (0.52) | GPR119SMARCA2SMARCA4PBRM1ABCB1 | |
| SCHEMBL17310160 | 0.84 | GPR119 (0.52) | GPR119SMARCA2SMARCA4PBRM1ABCB1 | |
| SCHEMBL17310159 | 0.84 | GPR119 (0.52) | GPR119SMARCA2SMARCA4PBRM1ABCB1 | |
| SCHEMBL21262363 | 0.83 | GPR119 (0.51) | GPR119SMARCA2SMARCA4PBRM1AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107108579-B | Imidazolidine-2, 4-dione derivatives as ADAMTS inhibitors for the treatment of osteoarthritis | 加拉帕戈斯股份有限公司 | 2019-12-17 | — | — | CN | disclosed |
| EP-3237406-A1 | 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | Galapagos NV (BE) | 2017-11-01 | — | — | EP | disclosed |
| WO-2016102347-A1 | 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2016-06-30 | — | — | WO | disclosed |