SCHEMBL17873752

SCHEMBL17873752

NCCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O

nearest known ligand 0.70

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 12/20 0.70
DDB1 Q16531 10/20 0.70
HDAC1 Q13547 5/20 0.65
HDAC2 Q92769 5/20 0.65
HDAC3 O15379 4/20 0.65
NCOR2 Q9Y618 4/20 0.65
IKZF3 Q9UKT9 2/20 0.62
TNF P01375 1/20 0.62
IL1B P01584 1/20 0.62
TBXA2R P21731 1/20 0.62
IKZF1 Q13422 1/20 0.62
STAT3 P40763 2/20 0.62
CA2 P00918 2/20 0.60
ALDH1A1 P00352 1/20 0.56
CHRM2 P08172 1/20 0.56
OPRM1 P35372 1/20 0.56
CYP1A2 P05177 1/20 0.56
TSHR P16473 1/20 0.56
TDP1 Q9NUW8 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29856029 0.99 CRBN (0.68) CRBNDDB1HDAC1HDAC2HDAC3
SCHEMBL19451294 0.99 CRBN (0.68) CRBNDDB1HDAC1HDAC2HDAC3
SCHEMBL22280101 0.99 CRBN (0.68) CRBNDDB1HDAC1HDAC2HDAC3
SCHEMBL24142128 0.99 CRBN (0.68) CRBNDDB1HDAC1HDAC2HDAC3
SCHEMBL19451416 0.99 CRBN (0.68) CRBNDDB1HDAC1HDAC2HDAC3
SCHEMBL23884378 0.99 CRBN (0.68) CRBNDDB1HDAC1HDAC2HDAC3
SCHEMBL17873760 0.99 CRBN (0.68) CRBNDDB1HDAC1HDAC2HDAC3
SCHEMBL23884163 0.99 CRBN (0.68) CRBNDDB1HDAC1HDAC2HDAC3
SCHEMBL21814694 0.99 CRBN (0.68) CRBNDDB1HDAC1HDAC2HDAC3
Hydrochloric Acid SCHEMBL30510193 0.99 CRBN (0.68) CRBNDDB1HDAC1HDAC2HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 144 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4734989-A2 SYNTHESIS AND IN VITRO CHARACTERIZATION OF PROTEOLYSIS TARGETING CHIMERAS (PROTACS) FOR DEGRADATION OF DNA METHYLTRANSFERASE 1 (DNMT1) Dana-Farber Cancer Institute, Inc. (US) 2026-05-06 EP disclosed
EP-4736882-A2 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE Cullgen (Shanghai), Inc. (CN) 2026-05-06 EP disclosed
EP-4731309-A1 KRAS PROTEOLYSIS TARGETING CHIMERAS Paq Therapeutics Inc. (US) 2026-04-29 EP disclosed
EP-3841098-B1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN SHANGHAI INC (CN) 2026-01-14 EP disclosed
US-20250388587-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN SHANGHAI INC (CN) 2025-12-25 US disclosed
US-20250325678-A1 CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN (CBP) AND/OR ADENOVIRAL E1A BINDING PROTEIN OF 300 KDA (P300) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN SHANGHAI INC (CN) 2025-10-23 US disclosed
US-20250325673-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2025-10-23 US disclosed
WO-2025216628-A1 PROTAC COMPOUNDS UNIVERSITEIT LEIDEN (NL) 2025-10-16 WO disclosed
EP-4613773-A2 IRAK DEGRADERS AND USES THEREOF Kymera Therapeutics, Inc. (US) 2025-09-10 EP disclosed
US-12410171-B2 Tropomyosin receptor kinase (TRK) degradation compounds and methods of use CULLGEN (SHANGHAI), INC. (CN) 2025-09-09 US disclosed
WO-2018081530-A1 COMPOSITIONS AND METHODS FOR TREATING EZH2-MEDIATED CANCER ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) 2018-05-03 WO disclosed
EP-3256470-A1 METHODS TO INDUCE TARGETED PROTEIN DEGRADATION THROUGH BIFUNCTIONAL MOLECULES Dana Farber Cancer Institute, Inc. (US) 2017-12-20 EP disclosed
WO-2017204445-A2 PHARMACEUTICAL COMPOSITION INDUCING DECOMPOSITION OF ALK PROTEIN, AND PHARMACEUTICAL COMPOSITION FOR CANCER PREVENTION OR TREATMENT CONTAINING SAME AS ACTIVE COMPONENT 한국화학연구원 2017-11-30 WO disclosed
WO-2017180417-A1 BET PROTEIN DEGRADERS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2017-10-19 WO disclosed
WO-2017176958-A1 MONOFUNCTIONAL INTERMEDIATES FOR LIGAND-DEPENDENT TARGET PROTEIN DEGRADATION THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2017-10-12 WO disclosed
WO-2017176957-A1 MDM2 PROTEIN DEGRADERS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2017-10-12 WO disclosed
WO-2017176957-A1 MDM2 PROTEIN DEGRADERS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2017-10-12 WO disclosed
WO-2017176958-A1 MONOFUNCTIONAL INTERMEDIATES FOR LIGAND-DEPENDENT TARGET PROTEIN DEGRADATION THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2017-10-12 WO disclosed
WO-2017024317-A2 METHODS TO INDUCE TARGETED PROTEIN DEGRADATION THROUGH BIFUNCTIONAL MOLECULES DANA-FARBER CANCER INSTITUTE, INC. (US) 2017-02-09 WO disclosed
WO-2016105518-A1 METHODS TO INDUCE TARGETED PROTEIN DEGRADATION THROUGH BIFUNCTIONAL MOLECULES DANA-FARBER CANCER INSTITUTE, INC. (US) 2016-06-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250325673-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 CRBN 187/4885DDB1 1267/4885HDAC1 502/4885
US-12410171-B2 Tropomyosin receptor kinase (TRK) degradation compounds and methods of use MUSK, ERBB2, NTRK1 CRBN 330/4885DDB1 480/4885HDAC1 1716/4885
US-20250388587-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE ERBB2, MUSK, ERBB3 CRBN 149/4885DDB1 1222/4885HDAC1 778/4885
US-20250325678-A1 CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN (CBP) AND/OR ADENOVIRAL E1A BINDING PROTEIN OF 300 KDA (P300) DEGRADATION COMPOUNDS AND METHODS OF USE CREBBP, EP300, CREB1 CRBN 109/4885DDB1 75/4885HDAC1 129/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.