Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18526414 | 0.90 | NPSR1 (0.43) | MEN1KMT2ASMN1; SMN2L3MBTL1HTT | |
| SCHEMBL17874319 | 0.86 | AOC3 (0.40) | MEN1KMT2ASMN1; SMN2L3MBTL1HTT | |
| SCHEMBL18526223 | 0.82 | MEN1 (0.46) | MEN1KMT2ASMN1; SMN2POLBCYP1A2 | |
| SCHEMBL17874232 | 0.82 | MEN1 (0.44) | MEN1KMT2ASMN1; SMN2POLBCYP1A2 | |
| SCHEMBL17887387 | 0.80 | FFAR2 (0.38) | L3MBTL1CYP19A1 | |
| SCHEMBL17874271 | 0.77 | MEN1 (0.39) | MEN1KMT2ASMN1; SMN2POLBCYP1A2 | |
| SCHEMBL17874270 | 0.73 | LMNA (0.46) | MEN1KMT2ASMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL18526413 | 0.73 | SMN1; SMN2 (0.39) | MEN1KMT2ASMN1; SMN2L3MBTL1HTT | |
| SCHEMBL18496621 | 0.73 | LMNA (0.40) | MEN1KMT2ASMN1; SMN2L3MBTL1HTT | |
| SCHEMBL18526569 | 0.73 | AOC3 (0.43) | MEN1KMT2ASMN1; SMN2L3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017025493-A1 | QUINOLINE EZH2 INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-02-16 | — | — | WO | disclosed |
| WO-2017025493-A1 | QUINOLINE EZH2 INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-02-16 | — | — | WO | disclosed |
| WO-2016102493-A1 | IMIDAZOPYRIDINE EZH2 INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-06-30 | — | — | WO | disclosed |
| WO-2016102493-A1 | IMIDAZOPYRIDINE EZH2 INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-06-30 | — | — | WO | disclosed |