Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16513114 | 0.90 | HSD11B1 (0.50) | HSD11B1EPAS1ALDH1A1CXCR2HPGD | |
| SCHEMBL18952971 | 0.89 | HSD11B1 (0.41) | HSD11B1EPAS1ALDH1A1KMT2AMEN1 | |
| SCHEMBL14063330 | 0.88 | HSD11B1 (0.46) | HSD11B1EPAS1NR4A2ALDH1A1CXCR2 | |
| SCHEMBL31150577 | 0.87 | KDM4E (0.48) | HSD11B1EPAS1ALDH1A1KMT2AMEN1 | |
| SCHEMBL852699 | 0.87 | KDM4E (0.48) | HSD11B1EPAS1ALDH1A1KMT2AMEN1 | |
| SCHEMBL17913590 | 0.86 | EPAS1 (0.45) | HSD11B1EPAS1NR4A2KMT2AMEN1 | |
| SCHEMBL6643810 | 0.85 | HSP90AA1 (0.43) | EPAS1NR4A2ALDH1A1CYP46A1CXCR2 | |
| SCHEMBL18952972 | 0.85 | KDM4E (0.42) | HSD11B1EPAS1ALDH1A1KMT2AMEN1 | |
| SCHEMBL5937228 | 0.85 | CYP46A1 (0.43) | EPAS1NR4A2ALDH1A1CYP46A1HPGD | |
| SCHEMBL27229877 | 0.81 | KDM4E (0.41) | HSD11B1EPAS1ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180065976-A1 | DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS | WILLIAM MARSH RICE UNIVERSITY (US) | 2018-03-08 | — | — | US | disclosed |
| US-9777013-B2 | Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents | WILLIAM MARSH RICE UNIVERSITY (US) | 2017-10-03 | — | — | US | disclosed |
| US-20160185791-A1 | DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS | WILLIAM MARSH RICE UNIVERSITY (US) | 2016-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160185791-A1 | DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS | UNC119, UNC93B1, RIOX2 | HSD11B1 4434/4885EPAS1 4136/4885NR4A2 4426/4885 |
| US-20180065976-A1 | DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS | UNC119, UNC93B1, RIOX2 | HSD11B1 4432/4885EPAS1 3965/4885NR4A2 4342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.