Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.43 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17879720 | 0.81 | BRD4 (0.56) | BRD4KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL15788367 | 0.80 | MAPK1 (0.42) | BAZ2BBAZ2AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL17879717 | 0.80 | UCHL1 (0.39) | BRD4BAZ2BBAZ2AKDM4EALDH1A1 | |
| SCHEMBL17517333 | 0.76 | ALDH1A1 (0.41) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL6803759 | 0.75 | ESR1 (0.49) | KDM4EALDH1A1GAAMAPK1TDP1 | |
| SCHEMBL7881193 | 0.73 | KMT2A (0.54) | KDM4EALDH1A1HPGDGAAMAPT | |
| SCHEMBL13295979 | 0.73 | ALDH1A1 (0.46) | BAZ2BBAZ2AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL22827048 | 0.72 | BRD4 (0.35) | BRD4BAZ2BBAZ2AKDM4EALDH1A1 | |
| SCHEMBL15788370 | 0.72 | ALDH1A1 (0.48) | KDM4EALDH1A1HPGDGAARXFP1 | |
| SCHEMBL24398095 | 0.72 | TNF (0.38) | BAZ2BBAZ2AKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9957263-B2 | Bromodomain inhibitors | ABBVIE INC. (US) | 2018-05-01 | — | — | US | disclosed |
| US-20160185769-A1 | Bromodomain Inhibitors | ABBVIE INC. (US) | 2016-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160185769-A1 | Bromodomain Inhibitors | BRD1, BRD4, BRD3 | BRD4 2/4885BAZ2B 12/4885BAZ2A 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.