Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAP1LC3B | Q9GZQ8 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 2/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3072328 | 0.76 | ALDH1A1 (0.47) | MAPTMAP1LC3BALDH1A1SMN1; SMN2HTT | |
| SCHEMBL2575397 | 0.74 | ALDH1A1 (0.47) | MAPTGAANPSR1MAP1LC3BALDH1A1 | |
| SCHEMBL16146464 | 0.73 | — | — | |
| SCHEMBL8407001 | 0.71 | ALDH1A1 (0.39) | MAPTGAANPSR1MAP1LC3BALDH1A1 | |
| SCHEMBL6837246 | 0.68 | MAPT (0.41) | MAPTGAANPSR1MAP1LC3BALDH1A1 | |
| SCHEMBL30255231 | 0.67 | MAPT (0.35) | MAPTGAANPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9889200 | 0.66 | — | — | |
| SCHEMBL9892466 | 0.66 | MEN1 (0.36) | GAAMEN1KMT2ATHRB | |
| SCHEMBL2574121 | 0.64 | MAPT (0.36) | MAPTGAANPSR1MAP1LC3BALDH1A1 | |
| SCHEMBL2574122 | 0.64 | MAPT (0.36) | MAPTGAANPSR1MAP1LC3BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237385-B1 | MUTANT IDH1 INHIBITORS USEFUL FOR TREATING CANCER | US HEALTH (US) | 2021-11-24 | — | — | EP | disclosed |
| US-10836759-B2 | Thiazole derivatives useful as mutant IDH1 inhibitors for treating cancer | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2020-11-17 | — | — | US | disclosed |
| US-20190241551-A1 | THIAZOLE DERIVATIVES USEFUL AS MUTANT IDH1 INHIBITORS FOR TREATING CANCER | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2019-08-08 | — | — | US | disclosed |
| WO-2016106331-A1 | MUTANT IDH1 INHIBITORS USEFUL FOR TREATING CANCER | THE UNITED STATES OF AMERICA (US) | 2016-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10836759-B2 | Thiazole derivatives useful as mutant IDH1 inhibitors for treating cancer | IDH1, IDH2, IDH3B | MAPT 3875/4885GAA 4210/4885NPSR1 4675/4885 |
| US-20190241551-A1 | THIAZOLE DERIVATIVES USEFUL AS MUTANT IDH1 INHIBITORS FOR TREATING CANCER | IDH1, IDH2, IDH3B | MAPT 3875/4885GAA 4210/4885NPSR1 4675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.