Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.64 |
| ▸ | TP53 | P04637 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5227854 | 0.87 | MTNR1A (0.63) | MTNR1ATP53LMNAMAPTHRH3 | |
| SCHEMBL5228137 | 0.87 | MTNR1A (0.67) | MTNR1ATP53LMNAMAPTPOLB | |
| SCHEMBL5227651 | 0.83 | MTNR1A (0.59) | MTNR1ATP53LMNAMAPTHRH3 | |
| SCHEMBL7297144 | 0.81 | MTNR1A (0.63) | MTNR1ATP53LMNAMAPTPOLB | |
| SCHEMBL16303447 | 0.80 | MTNR1A (0.58) | MTNR1ATP53LMNAMAPTHRH3 | |
| SCHEMBL5261920 | 0.79 | MTNR1A (1.00) | MTNR1ATP53LMNAPOLB | |
| SCHEMBL10177540 | 0.78 | HRH4 (0.43) | MTNR1AMAPTHRH3POLBSIGMAR1 | |
| SCHEMBL9082928 | 0.78 | MTNR1A (0.57) | MTNR1ATP53LMNAMAPTHRH3 | |
| SCHEMBL16303414 | 0.78 | MTNR1A (0.57) | MTNR1ATP53LMNAMAPTHRH3 | |
| SCHEMBL5227633 | 0.78 | MTNR1A (0.76) | MTNR1ATP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160185818-A1 | BIDENTATE-BINDING MODULATORS OF LRRK2 AND JNK KINASES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2016-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160185818-A1 | BIDENTATE-BINDING MODULATORS OF LRRK2 AND JNK KINASES | LRRK2, PINK1, MAP2K3 | MTNR1A 1721/4885TP53 1723/4885LMNA 3258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.