SCHEMBL17891202

SCHEMBL17891202

[O]CC(=O)C(C[C]=O)ON1C(=O)CCC1=O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17891130 0.88
SCHEMBL17890966 0.83
SCHEMBL4742746 0.72
SCHEMBL17891254 0.71
SCHEMBL8339775 0.66 HTT (0.36)
SCHEMBL17890963 0.65 KMT2A (0.31)
SCHEMBL11989420 0.63 PARL (0.31)
SCHEMBL13900968 0.63 PARL (0.31)
SCHEMBL1140513 0.62 ALDH1A1 (0.33)
SCHEMBL19446211 0.62 TSHR (0.37)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4349363-A2 DOSING REGIMENS Apellis Pharmaceuticals, Inc. (US) 2024-04-10 EP disclosed
US-11903994-B2 Dosing regimens APELLIS PHARMACEUTICALS, INC. (US) 2024-02-20 US disclosed
EP-3359555-B1 DOSING REGIMENS APELLIS PHARMACEUTICALS INC (US) 2023-12-20 EP disclosed
US-11844841-B2 Dosing regimens and related compositions and methods APELLIS PHARMACEUTICALS, INC. (US) 2023-12-19 US disclosed
US-20230091471-A1 CELL-REACTIVE, LONG-ACTING, OR TARGETED COMPSTATIN ANALOGS AND RELATED COMPOSITIONS AND METHODS SIXTH STREET LENDING PARTNERS 2023-03-23 US disclosed
US-20230009757-A1 COMBINATION THERAPY FOR C3 INHIBITION APELLIS PHARMACEUTICALS, INC. (US) 2023-01-12 US disclosed
EP-3660033-B9 LONG-ACTING COMPSTATIN ANALOGS AND RELATED COMPOSITIONS AND METHODS APELLIS PHARMACEUTICALS INC (US) 2022-06-22 EP disclosed
US-11338013-B2 Combination therapy for C3 inhibition APELLIS PHARMACEUTICALS, INC. (US) 2022-05-24 US disclosed
US-20210401997-A1 DOSING REGIMENS AND RELATED COMPOSITIONS AND METHODS SIXTH STREET LENDING PARTNERS 2021-12-30 US disclosed
EP-3929206-A1 LONG-ACTING COMPSTATIN ANALOGS AND RELATED COMPOSITIONS AND METHODS Apellis Pharmaceuticals, Inc. (US) 2021-12-29 EP disclosed
US-20200325175-A1 CELL-REACTIVE, LONG-ACTING, OR TARGETED COMPSTATIN ANALOGS AND RELATED COMPOSITIONS AND METHODS APELLIS PHARMACEUTICALS, INC. 2020-10-15 US disclosed
US-20200282012-A1 COMBINATION THERAPY FOR C3 INHIBITION APELLIS PHARMACEUTICALS, INC. (US) 2020-09-10 US disclosed
EP-3660033-A1 LONG-ACTING COMPSTATIN ANALOGS AND RELATED COMPOSITIONS AND METHODS Apellis Pharmaceuticals, Inc. (US) 2020-06-03 EP disclosed
US-20200038516-A1 DOSING REGIMENS AND RELATED COMPOSITIONS AND METHODS APELLIS PHARMACEUTICALS, INC. 2020-02-06 US disclosed
EP-2920201-B1 LONG-ACTING COMPSTATIN ANALOGS AND RELATED COMPOSITIONS AND METHODS APELLIS PHARMACEUTICALS INC (US) 2020-01-08 EP disclosed
US-20190194254-A1 CELL-REACTIVE, LONG-ACTING, OR TARGETED COMPSTATIN ANALOGS AND RELATED COMPOSITIONS AND METHODS SIXTH STREET LENDING PARTNERS 2019-06-27 US disclosed
US-10035822-B2 Cell-reactive, long-acting, or targeted compstatin analogs and related compositions and methods APELLIS PHARMACEUTICALS, INC. (US) 2018-07-31 US disclosed
US-20170283461-A1 CELL-REACTIVE, LONG-ACTING, OR TARGETED COMPSTATIN ANALOGS AND RELATED COMPOSITIONS AND METHODS APELLIS PHARMACEUTICALS, INC. 2017-10-05 US disclosed
US-20160215020-A1 CELL-REACTIVE, LONG-ACTING, OR TARGETED COMPSTATIN ANALOGS AND RELATED COMPOSITIONS AND METHODS APELLIS PHARMACEUTICALS, INC. (US) 2016-07-28 US disclosed
US-20160194359-A1 CELL-REACTIVE, LONG-ACTING, OR TARGETED COMPSTATIN ANALOGS AND RELATED COMPOSITIONS AND METHODS APELLIS PHARMACEUTICALS, INC. 2016-07-07 US disclosed