Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.49 |
| ▸ | MMP13 | P45452 | 7/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | FPR2 | P25090 | 3/20 | 0.47 |
| ▸ | MMP1 | P03956 | 4/20 | 0.46 |
| ▸ | MMP3 | P08254 | 3/20 | 0.46 |
| ▸ | MMP7 | P09237 | 3/20 | 0.46 |
| ▸ | MMP9 | P14780 | 3/20 | 0.46 |
| ▸ | MMP8 | P22894 | 3/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17892077 | 1.00 | NPC1 (0.51) | NPC1ALDH1A1MAPTMAPK1HTT | |
| SCHEMBL17892126 | 0.89 | ALDH1A1 (0.50) | NPC1ALDH1A1MAPTMAPK1HTT | |
| SCHEMBL17892067 | 0.89 | ALDH1A1 (0.50) | NPC1ALDH1A1MAPTMAPK1HTT | |
| SCHEMBL3881476 | 0.88 | GPR119 (0.59) | NPC1ALDH1A1MAPTMAPK1HTT | |
| SCHEMBL5934111 | 0.88 | MMP13 (0.60) | NPC1ALDH1A1MAPTMAPK1HTT | |
| SCHEMBL17892096 | 0.87 | ALDH1A1 (0.48) | NPC1ALDH1A1MAPTMAPK1HTT | |
| SCHEMBL4240647 | 0.86 | ALDH1A1 (0.52) | NPC1ALDH1A1MAPTMAPK1HTT | |
| SCHEMBL18321535 | 0.86 | ALDH1A1 (0.55) | NPC1ALDH1A1MAPTMAPK1HTT | |
| SCHEMBL4244525 | 0.86 | ALDH1A1 (0.52) | NPC1ALDH1A1MAPTMAPK1HTT | |
| SCHEMBL4239889 | 0.86 | ALDH1A1 (0.52) | NPC1ALDH1A1MAPTMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016109501-A1 | AMIDE COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2016-07-07 | — | — | WO | disclosed |