Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17892145 | 1.00 | ALOX5 (0.53) | ALOX5EPHX1CYP1A2MEN1KMT2A | |
| SCHEMBL29639815 | 0.83 | FFAR2 (0.47) | EPHX1SMN1; SMN2FFAR2 | |
| SCHEMBL9936881 | 0.82 | AKR1C3 (0.50) | ALOX5CYP1A2KMT2ASMN1; SMN2FFAR2 | |
| SCHEMBL16260345 | 0.82 | CYP1A2 (0.52) | ALOX5CYP1A2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL17892287 | 0.82 | AKR1C3 (0.50) | ALOX5CYP1A2KMT2ASMN1; SMN2FFAR2 | |
| SCHEMBL1885337 | 0.81 | KMT2A (0.58) | ALOX5CYP1A2KMT2ASMN1; SMN2FFAR2 | |
| Hydrochloric Acid SCHEMBL10921100 | 0.80 | AKR1C3 (0.49) | ALOX5CYP1A2KMT2ASMN1; SMN2FFAR2 | |
| SCHEMBL11316797 | 0.80 | FFAR2 (0.42) | FFAR2 | |
| SCHEMBL11406722 | 0.80 | AKR1C3 (0.49) | ALOX5CYP1A2KMT2ASMN1; SMN2FFAR2 | |
| SCHEMBL9966551 | 0.80 | CYP1A2 (0.46) | ALOX5CYP1A2MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016109501-A1 | AMIDE COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2016-07-07 | — | — | WO | disclosed |