Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 1/20 | 0.45 |
| ▸ | DPEP1 | P16444 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5453640 | 0.92 | DPP4 (0.40) | GCKDPEP1DPP4POLBHTR2A | |
| SCHEMBL22867975 | 0.81 | METAP2 (0.45) | NPC1RAB9AKMT2ASLC6A2SLC6A4 | |
| SCHEMBL10349212 | 0.81 | METAP2 (0.43) | DPP4 | |
| SCHEMBL22868100 | 0.80 | METAP2 (0.47) | NPC1RAB9AKMT2ASLC6A2SLC6A4 | |
| SCHEMBL9009370 | 0.79 | METAP2 (0.46) | — | |
| SCHEMBL28672429 | 0.79 | METAP2 (0.46) | — | |
| SCHEMBL28660567 | 0.79 | METAP2 (0.46) | — | |
| SCHEMBL12927229 | 0.79 | METAP2 (0.46) | — | |
| SCHEMBL7898573 | 0.79 | METAP2 (0.46) | — | |
| SCHEMBL17892144 | 0.79 | CHRNB2 (0.43) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016109501-A1 | AMIDE COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2016-07-07 | — | — | WO | disclosed |