Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 7/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.52 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.52 |
| ▸ | PRKACA | P17612 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | GSK3A | P49840 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.52 |
| ▸ | PRKX | P51817 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.52 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.52 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.52 |
| ▸ | MME | P08473 | 4/20 | 0.52 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17892264 | 0.85 | NPC1 (0.64) | TPH1L3MBTL1CTSKALPIPKM | |
| SCHEMBL17892360 | 0.85 | NPC1 (0.64) | TPH1L3MBTL1CTSKALPIPKM | |
| SCHEMBL12029124 | 0.80 | CTRB1 (0.71) | ROCK2RPS6KA5RPS6KA4PRKACAMAPK1 | |
| SCHEMBL414363 | 0.80 | SLC7A5 (0.78) | TPH1ALPIPKMPTGS1XIAP | |
| SCHEMBL93495 | 0.80 | SLC7A5 (0.78) | TPH1ALPIPKMPTGS1XIAP | |
| SCHEMBL180272 | 0.80 | SLC7A5 (0.78) | TPH1ALPIPKMPTGS1XIAP | |
| SCHEMBL93494 | 0.80 | SLC7A5 (0.78) | TPH1ALPIPKMPTGS1XIAP | |
| SCHEMBL1796036 | 0.80 | SLC7A5 (0.78) | TPH1ALPIPKMPTGS1XIAP | |
| SCHEMBL8231752 | 0.80 | EPHX2 (0.68) | TPH1ROCK2RPS6KA5PRKACAMAPK1 | |
| SCHEMBL14381168 | 0.80 | NR1H4 (0.64) | TPH1ALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016109501-A1 | AMIDE COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2016-07-07 | — | — | WO | claimed |