Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | TPH1 | P17752 | 9/20 | 0.61 |
| ▸ | ACACB | O00763 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | ALPI | P09923 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | XIAP | P98170 | 1/20 | 0.53 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.53 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17892264 | 1.00 | NPC1 (0.64) | NPC1RAB9ATPH1ACACBSMN1; SMN2 | |
| SCHEMBL17892320 | 0.85 | TPH1 (0.58) | NPC1RAB9ATPH1TP53ALPI | |
| SCHEMBL21394023 | 0.82 | ACACB (0.57) | NPC1RAB9ATPH1ACACBSMN1; SMN2 | |
| SCHEMBL414363 | 0.82 | SLC7A5 (0.78) | TPH1ALPIPKMPTGS1XIAP | |
| SCHEMBL1796036 | 0.82 | SLC7A5 (0.78) | TPH1ALPIPKMPTGS1XIAP | |
| SCHEMBL180272 | 0.82 | SLC7A5 (0.78) | TPH1ALPIPKMPTGS1XIAP | |
| SCHEMBL93495 | 0.82 | SLC7A5 (0.78) | TPH1ALPIPKMPTGS1XIAP | |
| SCHEMBL93494 | 0.82 | SLC7A5 (0.78) | TPH1ALPIPKMPTGS1XIAP | |
| SCHEMBL8231752 | 0.82 | EPHX2 (0.68) | NPC1RAB9ATPH1ALPIPKM | |
| SCHEMBL14381168 | 0.82 | NR1H4 (0.64) | TPH1SMN1; SMN2ALPIPKMPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016109501-A1 | AMIDE COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2016-07-07 | — | — | WO | claimed |